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Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站
一 |
据美联社、《纽约时报》等媒体报道，当地时间5月9日，中国籍亿万富豪覃辉被美国驱逐出境。他因以他人名义参与政治捐献、移民欺诈和伪造身份文件等罪名，达成认罪协议被判刑6个月，同意刑满释放后放弃绿卡，被美国驱逐出境。
2023年10月2日，覃辉在美国曼哈顿广场酒店的一间公寓里被捕，罪名是“使用虚假身份证件”。 
Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday.
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels.
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions.
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts.
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times.
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。他随后被指控以他人名义参与政治捐献、移民欺诈和伪造身份文件等罪名。
Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday.
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels.
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions.
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts.
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times.
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。他随后被指控以他人名义参与政治捐献、移民欺诈和伪造身份文件等罪名。
法庭文件显示，从2021年12月至2022年12月，覃辉以他人的名义向纽约市官员和国会候选人捐款1.6万美元，以骗取绿卡和佛罗里达州驾照。覃辉同意向那些被借用名义的人偿还他们支付的政治献金。
覃辉还承认， 2019年用不实资料申请美国永久居留权，之后还谎称自己从未用过别名，另于居住纽约期间以诈欺方式取得佛罗里达州驾照。2019年4月，他在向美国提交的LPR（绿卡）身份申请中，谎称从未使用过其他名字。实际上，他使用过化名“李木林”。
比如，2017年9月，覃辉就以李木林的名义，从中国向美国银行账户转账超过500万美元，其中一部分用于购买曼哈顿豪华公寓。
2023年9月，覃辉就曾被美国警方逮捕过一次，那次的理由是他试图袭击自己的前妻刘多。检察官透露，当时覃辉试图用斧头砸开一扇锁着的门。而在此几个月前，他还曾在另一起袭击中试图勒死前妻。
根据覃辉向曼哈顿高等法院提起的针对刘多的诉状显示，虽覃辉与刘多2021年在中国离婚，但两人到美国后依然住在一起，政治献金也是以刘多名义捐出。
根据公开资料，刘多在中国北京出生和长大，是2006年“中国小姐”和2008年中国模特大赛第一名，2010年通过“特殊人才计划”移民美国，在2017年成为美国公民。她曾被纽约市长办公室任命为“亚裔事务顾问委员会”成员。
二 |
2024年3月18日，覃辉在纽约东区联邦地区法院认罪。他被指控以他人名义参与政治捐献、移民欺诈和伪造身份文件等罪名。如不认罪，覃辉将面临最高27年的监禁，认罪后，刑期将下调为6个月，已服刑时间计入刑期。
覃辉承认从2021年纽约市长选举开始就利用自己的财产招募一些人，并出钱让他们代他捐出政治献金，但选举阵营并不知情。美媒报道称，他捐款的对象其中一人是纽约市长亚当斯，不过检察官说，所有竞选团队都不知道这些捐款是非法的。
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作为与检察官达成的协议的一部分，覃辉在本案中同意在服刑期满后离开美国，放弃美国绿卡，并被驱逐到美国以外的国家。
四 |
当时，覃辉的律师亨利·马祖里克表示：“我的当事人对案件得到解决感到高兴，他很高兴能了结此案，并期待着在美国以外的地方重新开始他的商业生涯。”
5月9日，在纽约长岛的法庭上，服刑期满的覃辉通过中文翻译向法官做了简短的发言，他流着泪为自己的行为道歉，称因为语言障碍，不太懂美国法律犯错。
覃辉眼含泪水表示，担心自己无法再见到生活在美国的3个孩子，孩子将来的毕业典礼等重要时刻他都无法参加，只盼未来与孩子们仍能保持联系。
覃辉的律师马祖里克告诉法官：“我的客户是中国一名白手起家的商人，他的3000多家连锁影院因新冠疫情而毁于一旦。他的公司倒闭了，他被人起诉，他的妻子离开了他。他在布鲁克林臭名昭著的拘留中心服刑，已经为自己的错误付出了代价。”
在法庭上，法官同意检方的建议，在服刑期满后将其释放，然后被驱逐出境。
五 | 覃辉被安排在几小时后飞往一个未指明的国家。他被美国联邦特工护送至机场，立即被永久驱逐出境。
在他提出安全考虑后，应他的要求，他去往哪个国家被保密。他曾要求不要被送往中国，他在中国欠了三家公司4.5亿美元的债务。
六 |
覃辉的律师马祖里克9日表示，覃辉已搭机离美，但他不愿指明目的地，仅说覃辉想要重建自己的生活。
七 |
现年56岁的覃辉曾以18亿美元的身家入围《福布斯》富豪榜。他曾是香港娱乐公司“星美文化”的董事长，该公司已解散。
覃辉更被中国网民熟悉的另一个身份是北京夜总会“天上人间”的老板。1995年，覃辉借款180万美元，买下了一家夜总会，并改名为“天上人间”，并将其发展成北京最知名的夜总会，内部极致奢华。2005年，已成烫手山芋的“天上人间”被覃辉转手卖掉。
2005年4月26日，覃辉因涉嫌行贿被批捕，在缴纳保证金后获准取保候审，从此淡出公众视野。据称，官司缠身的他从那以后远走美国。
2010年5月，因涉及有偿陪侍，“天上人间”和其他3家顶级娱乐场所被勒令停业整顿6个月，之后一直没有人再接手经营。
来 源：华商报大风新闻
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